City will not extend the contracts of defenders Gael Clichy and Bacary Sagna, midfielder Jesus Navas and goalkeeper Willy Caballero as the quartet will leave the club during the summer.
They join Pablo Zabaleta, who said his goodbyes after their penultimate Premier League win over West Brom last week.
Caballero, Navas and Sagna made 16 or fewer league starts for City this season, while Clichy, 31, started 24 games.
Sagna told the club’s website: “I have enjoyed every moment of my City career and will look back on my time at City fondly.
“From the first day I arrived, everyone at the club has made me feel welcome and I will always be grateful to them.”
Clichy added: “It’s been a special six years for me at City.
“To win four major trophies and help establish the Club as one of the top teams in English football has been an incredible journey that I’m proud to have been a part of.
“It’s amazing to see where the Club is today and I am sure there is plenty more success to come.”